Phytomedicines (plant-derived drugs) express a vast array of biological activities and therefore, phytomedicines have been practiced worldwide since the ancient times for the prevention and treatment of the diseases. However, various chemical and biological barriers like insolubility, hydrophobicity, low bioavailability, and high toxicity restrict the application of such imperative phytomedicines.

Phyto Nanoparticle-based drug-delivery systems enhance delivery of herbal drugs to their respective target(s). In this chapter, we summarize the role of drug-delivery systems used for phytomedicines and their potential to deliver phytomedicines
against assorted life-threatening diseases.